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Further evidence of an autoimmune nature is the presence of speci c autoantibodies in nearly half of cases as described earlier Immunopathologic studies have partially substantiated an autoimmune mechanisms and suggested, in addition, that PM and DM can be distinguished from one another on the basis of their immunopathologic characteristics In DM, immune complexes, IgG, IgM, complement (C3), and membrane-attack complexes are deposited in the walls of venules and arterioles, indicating that the immune response is directed primarily against intramuscular blood vessels (Whitaker and Engel; Kissel et al) Such a response is entirely lacking in PM (and in IBM, discussed further on) Engel and Arahata have demonstrated a difference between the two disorders on the basis of the subsets and locations of lymphocytes that make up the intramuscular in ammatory aggregates.

In PM, there are a large number of activated T cells, mainly of the CD8 class, whereas B cells are sparse Moreover, T cells, accompanied by macrophages enclose and invade nonnecrotic muscle bers In DM, very few.

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In neurology more than any other specialty, the physician is dependent upon the cooperation of the patient for a reliable history, especially for a description of symptoms that are unaccompanied by observable signs of disease. And if the symptoms are in the sensory sphere, only the patient can tell what he* sees, hears, or feels. The rst step in the clinical encounter is to enlist the patient s trust and cooperation and make him realize the importance of the examination procedure. The practice of making notes at the bedside or in the of ce is particularly recommended. Immediate recording of the history assures maximal reliability. Of course, no matter how reliable the history appears to be, veri cation of the patient s account by a knowledgeable and objective informant is always desirable. The following points about taking the neurologic history deserve further comment: 1. Special care must be taken to avoid suggesting to the patient the symptoms that one seeks. In the clinical interview, the

Let frame a be aligned with frame b by rotating frame a by radians about unit vector E. The quaternion b that represents the rotational transformation from frame a to frame b is b= cos( /2) E sin( /2) .

whichrepresentstruepercent relative a I errorof 1.3 percent an approximate 0f and enor il r082 1 6.2758 - 6.70 1 l c .l ,: l - l x 6.17581 1 | I : 1001 6.116(/t

Animal experiments suggest that the corticoreticulospinal pathways are particularly important in this respect, since their bers are arranged somatotopically and are able to in uence stretch re exes Further studies of human disease are necessary to settle problems related to volitional movement and spasticity The motor organization of the cat and even of the monkey is so different from that of humans, and the range of volitional activity and motor skills is so much less in animals, that direct comparisons are not justi ed The distribution of the paralysis due to upper motor neuron lesions varies with the locale of the lesion, but certain features are characteristic of all of them A group of muscles is always involved, never individual muscles, and if any movement is possible, the proper relationships between agonists, antagonists, synergists, and xators are preserved.

Test the zoom in and zoom out buttons. When you zoom in, you should see something that looks similar to the following illustration.

It won t surprise the reader who has gotten this far to read again that integrity is a key part of the Lombardi leadership model Integrity means having an upright, honest, and complete character In a different, but related, sense, the word means that throughout its whole, an object is of uniform consistency and strength No matter where one applies pressure or stress, one gets an equal and consistent response This is structural integrity Integrity permeates behaviors My father referred to integrity as character in action You develop integrity after you have determined your principles and values This suggests that it is an outer expression of your inner character It is the manifestation of an unshakable set of principles that you will not violate under any circumstances Leaders have to impress upon those around them an idea of who and what they are.

Isolating only two of the ASP.NET 3.5 controls as rich data controls may be slightly misleading because so many of the controls can be considered rich data controls. Some of these controls are discussed elsewhere simply as web controls, and others are specialized, such as the new LINQ controls that are examined in 14 and the special file controls discussed in 15. For now, though, the Calendar and AdRotator controls stand as examples of controls that are rich in properties and functionalities. They add a whole new level of functionality with a minimum of coding and configuration.

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