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They wrote: Psychology bears a social responsibility to provide the best available evidence on important questions of legal policy whenever it can do so (APA, Principle F) It should proceed with caution but it should not be disabled by a requirement for perfect evidence (Goodman, Levine, & Melton, 1992, p 249) TheAPA-sponsored brief in Lockhart v McCree has also been criticized as possibly overstating the value of the relevant research (Elliot, 1991a, 1991b), and those criticisms were answered as well (eg, Ellsworth, 1991) It seems likely that debates will continue, both within psychology and from those outside the eld, about the relevance and applicability of evidence based upon psychological research studies Even when the US Supreme Court chooses to pay attention to data included in a scienti c brief, the Court may not always reach the conclusion that the brief s writers intended.

In 1994, our idea to generate 3-dimensional cardiac tissue constructs came from the observation that it is relatively easy to genetically manipulate cultured immature cardiac myocytes in the classic 2-dimensional culture format (and to observe biochemical or molecular consequences) but dif cult to obtain reliable information from these cells in terms of contractile function Evaluation of contractile consequences of any genetic manipulation would be essential, however, for the validation of potentially relevant genes identi ed by gene expression arrays that we and others performed at that time The description of a method to culture embryonic chick broblasts in collagen I in a 3-D format that allowed measurement of (tonic) contractile forces in the organ bath by the group of E L Elson [Kolodney and Elson, 1993] stimulated us to adapt the method to embryonic chick cardiac myocytes.

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A case in point is the issue of jury size The APA submitted an amicus brief in Williams v Florida (1970) presenting research that, the brief s writers felt, indicated that juries consisting of fewer than 12 members were undesirable because they were unlikely to maintain a representative cross-section.

In general, when multiple indicators of a factor are available, they should be incorporated into the analysis In particular, it is not appropriate to conduct SEM analyses on relations among scale scores when multiple indicators are available for at least some (most or all) of the constructs, thereby negating many of the advantages of the CFA /SEM approach (also see Shah & Goldstein, 2006) Item Parcels It is better to have more indicators per factor There is, however, an understandable reluctance on the part of applied researchers to incorporate large numbers of indicators per factor, particularly in large complex models that involve many different factors Also, there can be technical problems in estimation when the total number of indicators approaches N One potentially useful compromise is to collect a large number of indicators per factor, but to use indicator parcels in the analyses.

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The experiments quickly yielded success, and cardiac myocytes spontaneously generated a coherently and regularly beating cardiac tissue-like structure (cardiac myocyte-populated matrix, CMPM) that developed measurable forces when suspended in organ baths and connected to a force transducer [Eschenhagen et al, 1997] The success was surprising because others had described that cardiac myocytes from neonatal rats do not grow inside a collagen I matrix but can only be cultured on top of a preformed collagen I matrix [Souren et al, 1992] We later learned that, indeed, cardiac myocytes from neonatal rats, in contrast to embryonic chick cardiac myocytes, did not spontaneously form a tissuelike structure when cultured in collagen I, but needed supplementation of Matrigel and a modi cation of the cell-matrix composition in the original reconstitution mixture [Zimmermann et al, 2000] The initial experimental setup followed the one proposed by E L Elson s group in St.

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